Action of nonsteroidal, anti inflammatory drugs on human and rat peripheral leucocyte migration in vitro

Abstract

Using an in vitro system of cell migration from glass capillary tubes, the nonsteroidal, anti inflammatory agents sodium salicylate, aspirin, ibuprofen, phenylbutazone, and indomethacin were shown to inhibit the migration of human peripheral leukocytes in a dose related manner. This drug action was not confined to one species, as shown by the modification of rat peripheral leukocyte motility by sodium salicylate and aspirin. The relevance of the human findings to the clinical effectiveness of these agents is discussed.