Hydroxyapatite/ZnCl2 nano-flakes: An efficient catalyst for the synthesis of 2-arylbenzothiazoles with molecular docking and anti-oxidant evaluation

Abstract

Synthesis of 2-substituted benzothiazole derivatives using ZnCl2 nano-flakes supported on nano-hydroxyapatite as a catalyst. Has been achieved by one-pot reaction of 1 mole of aromatic heterocyclic aldehydes with 1 mole of 2-aminothiophenol under solvent – free condition. The adopted reaction has many characteristics: fast, efficacious, eco-friendly and short time ZnCl2/HAp catalyst was synthesized and identified using X-ray diffraction, Scanning Electron Microscopy, and Fourier transforms infrared. The obtained results explained the formation of nano-crystalline sheets over the hydroxyapatite nano-matrix. The molecular docking validation as transpeptidase and 14 α-demethylase enzyme inhibitors explains that there are five for the synthesized compounds that give good energy score values. Also, the anti-oxidant study showed that four 2-benzothiazoles of the synthesized compounds gave promised ABTS (Inhibition %) compared with ascorbic acid.