Albumin nanoparticles fabricated from microscaled PLGA templates using layer-by-layer assembly

Abstract

The size of particles is a principal parameter to design drug delivery vehicles. In this work, albumin nanoparticles were fabricated from microscaled poly[lactic-co-(glycolic acid)] (PLGA) templates using layer-by-layer (LbL) assembly, which are different from traditional LbL-based hollow capsules. The albumin nanoparticles exhibit a spherical shape and solid inner structure. The formation mechanism of these albumin nanoparticles was proposed based on PLGA templates, mechanical property of albumin and external sonication.