Intracerebral hemorrhage is the most devastating stroke subtype with high rates of mortality and morbidity. Furthermore, no clinically approved treatment exists that effectively increases survival or improves quality of life for survivors. Effective modeling is necessary to elucidate the pathophysiological mechanisms of intracerebral hemorrhage and evaluate potential therapeutic approaches. Rodent models are most utilized because of their cost-effectiveness, and because rodent brain development and structures are well documented. Herein, we describe two intracerebral hemorrhage mouse models: the autologous blood double-injection and collagenase infusion models.
CITATION STYLE
Klebe, D., Iniaghe, L., Burchell, S., Reis, C., Akyol, O., Tang, J., & Zhang, J. H. (2018). Intracerebral hemorrhage in mice. In Methods in Molecular Biology (Vol. 1717, pp. 83–91). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7526-6_7
Mendeley helps you to discover research relevant for your work.