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Structure of the Inhibited State of the Sec Translocon

Molecular Cell (2020) 79(3) 406-415.e7
DOI: 10.1016/j.molcel.2020.06.013
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Abstract

Gérard et al. determine the structure of the mammalian Sec translocon in an inhibited state. Mycolactone holds the translocon in a conformation optimal for substrate engagement, wedging open the cytosolic side of the lateral gate, while also blocking the path taken by the signal peptide during engagement.

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Gérard, S. F., Hall, B. S., Zaki, A. M., Corfield, K. A., Mayerhofer, P. U., Costa, C., … Higgins, M. K. (2020). Structure of the Inhibited State of the Sec Translocon. Molecular Cell, 79(3), 406-415.e7. https://doi.org/10.1016/j.molcel.2020.06.013

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