Asymmetric syntheses of functionalized pyrrolizidin-3-ones

Abstract

The syntheses of 1- and 7-hydroxypyrrolizidin-3-ones are described via asymmetric catalytic hydrogenation or diastereoselective reduction of ketones as key steps. 2, 7-Disubstituted pyrrolizidin-3-ones are also prepared. The second chiral center is created using stereoselective electrophilic amination or hydroxylation reactions. © ARKAT-USA, Inc.