New flavan and benzil isolated from Fissistigma latifolium

Abstract

Further investigation of the methanolic extract of Fissistigma latifolium resulted in two new compounds whose structures were assigned as 2,5,6,7-tetramethoxyflavan (1) and 2′-hydroxy-4′,5′,6′- trimethoxybenzil (2). These two compounds were determined on the basis of chemical and spectroscopic evidences. Compound 2 is the first report of benzil from Fissistigma species. 2,5,6,7-Tetramethoxyflavan (1) showed a potent inhibitory effect on superoxide anion production in formyl-L-methionyl-L-leucyl- L-phenylalanine (fMLP)/cytochalasin B (CB)-activated human neutrophils. © 2012 The Pharmaceutical Society of Japan.