Multidrug-resistant tuberculosis detection, Latvia

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Abstract

To improve multidrug-resistant tuberculosis (MDR-TB) detection, we successfully introduced the rpoB gene mutation line probe assay into the national laboratory in Latvia, a country with epidemic MDR-TB. The assay detected rifampin resistance with 91% sensitivity and 96% specificity within 1 to 5 days (vs. 12-47 days for BACTEC).

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Skenders, G., Fry, A. M., Prokopovica, I., Greckoseja, S., Broka, L., Metchock, B., … Leimane, V. (2005). Multidrug-resistant tuberculosis detection, Latvia. Emerging Infectious Diseases, 11(9), 1461–1463. https://doi.org/10.3201/eid1109.041236

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