Synthesis of carboxylic acid derivatives of 2-pyrazolines

Abstract

2-Pyrazolines 7-12 bearing a carboxylic acid ester or a carboxamide side-chain have been prepared by treatment of the appropriate chalcone derivatives 2-6 with hydrazine hydrate or phenylhydrazine in hot acetic acid. 1-(2-Carboxyphenyl)-2-pyrazolines 24-30 and 1-(4-carboxyphenyl)-2-pyrazolines 31-41 were synthesized by the reaction of chalcones with (2-carboxyphenyl) hydrazine and (4-carboxyphenyl)hydrazine in hot acetic acid. Structures of all new compounds have been elucidated by microanalyses, 1H-, 13C-NMR and IR spectroscopic measurements. ©ARKAT USA, Inc.