Enfermedades priónicas y enfermedades similares a priones

Abstract

Prion diseases are a group of neurodegenerative diseases with a global impact of 1 to 2 cases per million, mostly ignored by the physician. Even though these diseases affect primarily the central nervous system, recently, alterations in diverse systems of the organism have been found. On the other hand, it has been shown that neuro-degenerative diseases like Parkinson and Alzheimer disease, possess similar mechanisms in their physiopathology to those found in prion disease. The objective of this review is to contribute knowledge andcomprehension about epidemiology, etiology, clinical manifestations, diagnosis and the current state of researches for possible treatments on prion disease. This was done through researching information from PubMed, Science Direct, Europe PMC, Google Scholar, Scielo y Redalyc. It was pinpointed that amongst the most promising technologies for the diagnosis of prion disease is the Real-Time Quaking-Induced Conversion; there are research for the treatment of prion disease that are in initial stages; and that the knowledge of the similar mechanisms to prions on chronic-degenerative disease can contribute to a better understanding of them.