Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease

31Citations
Citations of this article
26Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The endothelial dysfunction has been implicated as a major event in the pathogenesis of atherosclerosis. Therefore, this study was planned to determine (a) role of endothelium-derived nitric oxide (NO) and endothelin as coronary artery disease (CAD) risk markers and (b) intergenotypic variation of endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism in CAD.The endothelin, NO and eNOS genotypes were determined in 60 patients with documented history of CAD. These were compared with 50 age- and sex- matched healthy controls. The genotype frequencies for eNOS gene polymorphism were determined by PCR and RFLP. The plasma endothelin in CAD patients was significantly higher (p< 0.001) whereas, the NO level in CAD group was significantly lower (p< 0.001) than the control group. The genotype frequencies for Glu298/Asp (Glu/Glu and Glu/Asp) genotypes were 75% and 25% in CAD subjects and 88% and 12% in control subjects, respectively. No Asp/Asp was found in any of the groups. The genotype frequencies differed significantly (p< 0.05) between the controls and cases. In conclusion, endothelin and NO may be used as markers of endothelial dysfunction in CAD. Asp allele might be a risk factor for CAD in the North Indian population. © 2011 - IOS Press and the authors. All rights reserved.

References Powered by Scopus

Atherosclerosis - An inflammatory disease

20152Citations
N/AReaders
Get full text

Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the multiple risk factor intervention trial

3688Citations
N/AReaders
Get full text

Nitric oxide decreases cytokine-induced endothelial activation: Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines

1634Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease

69Citations
N/AReaders
Get full text

Association of endothelial nitric oxide synthase gene polymorphisms with coronary artery disease: An updated meta-analysis and systematic review

51Citations
N/AReaders
Get full text

Endothelin-1 but not endothelial nitric oxide synthase gene polymorphism is associated with sickle cell disease in Africa

21Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Saini, V., Bhatnagar, M. K., & Bhattacharjee, J. (2011). Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease. Disease Markers, 31(4), 215–222. https://doi.org/10.1155/2011/419708

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 12

60%

Researcher 5

25%

Professor / Associate Prof. 2

10%

Lecturer / Post doc 1

5%

Readers' Discipline

Tooltip

Medicine and Dentistry 9

41%

Agricultural and Biological Sciences 6

27%

Biochemistry, Genetics and Molecular Bi... 4

18%

Pharmacology, Toxicology and Pharmaceut... 3

14%

Save time finding and organizing research with Mendeley

Sign up for free