Histopathological overview of mice duodenum (Mus musculus) due to carbofuran exposure

Abstract

The aim of this study was to explore small bowel tissue injury through duodenal histopathology of mice (Mus musculus) exposed to carbofuran. The measured parameter was duodenal epithelial integrity. The experiment involved thirty female mice, divided into four treatment groups: P0 (control) was not exposed to carbofuran but substituted with 0.9% NaCl; P1 was exposed to 0.0104 mg/kg Body Weight of carbofuran; P2 was exposed to 0.0208 mg/kg Body Weight of carbofuran; P3 was exposed to 0.0407 mg/kg Body Weight of carbofuran. The experimental design was a completely randomized design with four treatments and five replications. Data were analyzed using the Kruskal-Wallis test, followed by the Mann-Whitney test if there were significant differences among treatment groups. The results suggested that carbofuran exposure caused desquamation and epithelial erosion, with the effective dose for duodenal histopathology change being 0.208 mg/kg Body Weight.