Research of psychotropic properties of Xanton-containing plants

Abstract

In the modern world, unfavorable environmental conditions, together with a difficult social situation, often lead to an increase in the number of neuropsychiatric disorders, and, as a consequence, to an increase in the use of neurotropic drugs, such as anxiolytics, antipsychotics and psychostimulants. Currently, a very urgent world problem is the search for various biologically active agents that have anti-anxiety and psychotropic activity without negative impact on the psychomotor and cognitive functions of the body and, first of all, these are herbal products. As a result of the study, it was shown that extracts from plant raw materials Hedysarum alpinum L. and Garcinia mangostana L. have a more pronounced effect on changing the behavior of animals under the conditions of the forced unavoidable swimming test according to the Porzolt method compared to piracetam. Against the background of the introduction of the extract of Hedysarum alpinum L., there was no significant change in the orientation-exploratory behavior in comparison with the control animals, while the reference drug haloperidol had a depressing effect on it. The obtained experimental data suggest that the extract of Hedysarum alpinum L. has an antipsychotic effect in the absence of a depriming effect. In the group receiving the extract of Garcinia mangostana L., there was also no significant change in orientation-exploratory behavior compared with animals in the control group. The result of the experiment allows us to make a conclusion about the presence of anti-anxiety activity in the extract of Garcinia mangostana L., in the absence of a depriming effect.