Dipole density mapping of atrial fibrillation

Abstract

Atrial fibrillation (AF) is a complex, patient-specific arrhythmia. For those with persistent AF current standard of care is no different than for patients with paroxysmal AF, yet outcomes are considerably inferior. The AcQMap System has been developed to provide a diagnostic tool that can locate the cardiac tissue responsible for an arrhythmia and precisely target areas for treatment whilst minimizing delivery of redundant therapy. Early clinical results demonstrate accurate left atrial reconstruction when compared to pre-procedural CT/MRI with dipole density mapping offering a>4-fold higher resolution than voltage-based mapping. The system has successfully mapped stable and unstable atrial arrhythmias without additional patient risk. The ability to quickly remap reveals new targets and visualization of activation pattern changes without any prolongation of procedure time. Progressive AcQMap ElectroFunctional strategies (map, ablate, remap) break down the complexity of AF often resulting in arrhythmia termination and sinus rhythm. The advanced performance of AcQMap is likely to represent a significant advance in treating persistent AF when compared to voltage-based 3D mapping systems that also require tissue-contact.