Nucleoside-metallacarborane conjugates: Synthesis of a uridine-bearing 3,3,3-(CO)3-closo-3,1,2-ReC2B9H10 complex

Abstract

A new type of nucleoside-metallacarborane conjugate is presented. 3,3,3-Tricarbonyl-closo- 3,1,2-ReC2B9H10 is used as a modifying unit. The method is based on the de novo formation of a metallacarborane complex via the reaction of [NEt4] 2[ReBr3(CO)3] with the uridine-bearing carborane as a boron cluster ligand. The uridine-tricarbonyl rhenacarborane represents an example of a novel type of nucleoside-metallacarborane conjugate bearing a therapeutically important rhenium component. © ARKAT-USA, Inc.