CTLA4 tagging polymorphisms and risk of colorectal cancer: A case–control study involving 2,306 subjects

Abstract

Background: CTLA4 is a candidate gene which has been implicated in the development of colorectal cancer (CRC). Patients and Methods: To determine the important role of CTLA-4 polymorphisms on risk of CRC, we genotyped four CTLA-4 tagging polymorphisms and calculated crude/adjusted ORs with their 95% CIs. We recruited 1,003 sporadic CRC cases and 1,303 controls. Results: The findings suggested that CTLA-4 rs231775 G <0.001, <0.001, and 0.002, respectively). Conclusion: This study evidences an association of CTLA-4 tagging polymorphisms and haplotypes with CRC risk. Additional well-designed studies with large sample sizes are required to confirm our findings.