Synthesis, bioactivity, molecular docking and POM analyses of novel substituted thieno[2,3-b]thiophenes and related congeners

23Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

Abstract

Several series of novel substituted thienothiophene derivatives were synthesized by reacting the synthone 1 with different reagents. The newly synthesized compounds were characterized by means of different spectroscopic methods such as IR, NMR, mass spectrometry and by elemental analyses. The new compounds displayed significant activity against bothGram-positive and Gram negative bacteria, in addition to fungi. Molecular docking and POM analyses show the crucial role and impact of substituents on bioactivity and indicate the unfavorable structural parameters in actual drug design: more substitution doesn't guaranty more efficiency in bioactivity.

Cite

CITATION STYLE

APA

Mabkhot, Y. N., Aldawsari, F. D., Al-Showiman, S. S., Barakat, A., Hadda, T. B., Mubarak, M. S., … Rauf, A. (2015). Synthesis, bioactivity, molecular docking and POM analyses of novel substituted thieno[2,3-b]thiophenes and related congeners. Molecules, 20(2), 1824–1841. https://doi.org/10.3390/molecules20021824

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free