The effects of oral sedatives on the vasoconstrictive reaction to fear

Abstract

Summary: The effects of several drugs administered orally on the vasoconstrictive reaction to fear have been studied in 350 patients. Nitrazepam 10 mg was the most effective in producing sedation and in preventing the vasoconstrictive reaction to fear in the immediate preoperative period. The hypnotic effect of nitrazepam was augmented by droperidol 20 mg also administered orally. Nitrazepam completely suppressed the dysphoric and extra-pyramidal reactions to droperidol. No undesirable side effects were seen when the drugs were used simultaneously. Prolonged postoperative sleepiness may be objectionable in certain circumstances. © 1971 John Sherratt and Son Ltd.