Synthesis and In-Vitro Antimicrobial Activity of N-Benzamide Derivatives

Abstract

Amide derivatives of benzoic acids have a wide range of pharmacological effects, including analgesic, anti-inflammatory, anti-cancer, cardiovascular, and other biological effects, as well as antimicrobial, antibacterial, and antifungal effects. These biological implications draw the scientific community to create numerous novel benzamide derivatives. The synthesis of 12 benzamide compounds and their antibacterial activity profile are the subjects of the current investigation. Compound 5a showed remarkably excellent activity against both the strains B. subtilis and E. coli with a diameter zone of inhibition 25 and 31 mm and MIC values of 6.25 for B. subtilis and 3.12 μg/mL for E. coli, respectively. However, compounds 6b and 6c showed better activity against E. coli and B. subtilis with a 24 mm diameter zone of inhibition and have 3.12 and 6.25 μg/mL MIC values, respectively.