The Use of the Mitochondrial Toxin 3-NP to Uncover Cellular Dysfunction in Huntington’s Disease

Abstract

Degenerative diseases that affect the nervous system are characterized by a progressive alteration of specific neuronal populations and normally end in cell death. Some neurodegenerative disorders exhibit a clear genetic origin, such as in the case of Huntington’s Disease (HD); however, most neurodegenerative diseases do not have a genetic cause, suggesting that other mechanisms cause these alterations.