Investigation of singlet oxygen production property of peripherally tetra-substituted in(Iii)ci phthalocyanine for photodynamic therapy

Abstract

Phthalocyanines (Pcs) are macrocyclic compounds of great importance. Different metals and ligands can be used in the synthesis of Pc compounds and they give different properties to Pcs. Thus, the applications of Pcs have been increasing every day. One of the most important areas of use of Pcs is photodynamic therapy (PDT) application. The scope of this study is synthesis, characterization, and investigation of singlet oxygen generation property of new peripherally tetrakis(benzodioxane) substituted indium(III) chloride phthalocyanine (InCIPc). The compound may be used as a potential photosensitizer for PDT applications. The new compound was characterized by various techniques such as elemental analysis, FT-IR,1H NMR, MS, and UV–Vis techniques. Furthermore, photophysical and photochemical properties of the synthesized Pc were investigated for PDT studies. At the same time, the effect of combination of heavy indium atom and benzodioxane groups bearing oxygen atom on solubility and photophysicochemical properties was discussed. The results showed that this compound exhibits good solubility in DMSO and shows high singlet oxygen production (ΦΔ: 0.76). According to the displayed properties and singlet oxygen production, we can say that this compound is a potential candidate for PDT applications.