Daytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5% and dorzolamide 2%/timolol maleate 0.5%

Abstract

Purpose. The diurnal efficacy and safety of the fixed combinations of latanoprost/timolol given once daily vs dorzolamide/timolol given twice daily in primary open-angle glaucoma or ocular hypertensive patients. Design. A double-masked, two-centre, crossover comparison. Results. In 33 patients, the mean diurnal IOP (0800-2000, measured every 2 h) for latanoprost/ timolol fixed combination was 17.3± 2.2 mmHg and for dorzolamide/timolol, the fixed combination was 17.0 ± 2.0 mmHg (P = 0.36). Additionally, there was no statistical difference for individual time points following a Bonferroni correction. A bitter taste was found more frequently with the dorzolamide/timolol fixed combination (n = 6) than the latanoprost/ timolol fixed combination (n = 0) (P = 0.040), while the latanoprost/timolol fixed combination demonstrated more conjunctival hyperaemia (n = 9) than the dorzolamide/timolol fixed combination (n = 2) (P = 0.045). One patient was discontinued early from the dorzolamide/ timolol fixed combination due to elevated IOP. Conclusion. This study suggests that the daytime diurnal IOP is not statistically different between the dorzolamide/timolol fixed combination and latanoprost/timolol. fixed combination in primary open-angle glaucoma and ocular hypertensive patients. © 2004 Nature Publishing Group All rights reserved.