Comparative trial of iohexol 350, A non-ionic contrast medium, with diatrizoate (Urografin 370) in left ventriculography and coronary arteriography

Abstract

In a prospective double blind randomised study in 25 consecutive patients a conventional ionic contrast medium (Urografin 370) was compared with the new non-ionic medium iohexol 350 (Omnipaque) in left ventriculography and coronary arteriography. In left ventriculography there was a clear patient preference for iohexol by both a visual analogue scale and independent observer assessment. Iohexol also induced a smaller increase in heart rate or decrease in systolic blood pressure than Urografin. In coronary arteriography iohexol resulted in a smaller reduction in heart rate and systolic blood pressure, a smaller maximum increase in RR interval, less prolongation of the PQ and QT intervals and QRS duration, and a lower incidence of induced chest pain, ST segment depression, or T wave deflection.