Dealcoholised beers reduce atherosclerosis and expression of adhesion molecules in apoE-deficient mice

Abstract

Polyphenols exert beneficial effects in atherosclerosis. The crucial step in atherosclerosis is the recruitment of monocytes to the subendothelial space, induced by endothelial adhesion molecules through the activation of factors such as NF-B. We studied the effect of a dealcoholised lager beer (DLB) and a dealcoholised dark beer (DDB) on atherosclerotic lesions, and the underlying mechanisms. Dealcoholised beers were administered in the diet (42ml/kg body weight per d) to 4-week-old male apoE knockout (apoE-/-) mice for 20 weeks. The atherosclerotic lesions in the thoracic aorta were reduced by 44% (P=·003) and 51% (P