Evaluation of serum amylase and serum lipase as biochemical markers of pancreatic exocrine function in type II diabetes mellitus

Abstract

Background: Diabetes mellitus is a metabolic ailment characterized by hyperglycemia in which there is a severe derangement of the endocrine functionality of  the pancreas. Studies have demonstrated the association of pancreatic enzymes as biomarkers of exocrine function in DM-II. Material and methods: In this case-controlled study total 90 subjects were included, which were separated into two groups DM (n=45) and non-DM (n=45). The non-diabetic control group was age and sex-matched. After inclusion, written informed consent was acquired from all the individuals and they were investigated for serum amylase and lipase levels. Other routine investigations were also done. The data was then recorded and statistical analyses were done. Results: This study showed that mean amylase in DM group (44.69±15.57) was lesser than in non-DM group (60.69±21.67). Similarly, the mean lipase in DM group (35.44±11.30) was lesser than in non-DM group (48.47±12.73). With increase in Glycated haemoglobin, both enzyme levels decreased substantially when assessed with the non-DM groups. It was also showed that in patients with higher LDL (> 110) the serum amylase levels decreased further compared to the non-DM patients. Similar results were reported for serum lipase also.