Role of Phytochemicals against Diabetic Nephropathy: An Insight into Molecular Receptors

Abstract

Diabetic nephropathy is a growing disorder among diabetic patients. A multifactorial disorder affects various factors like elevated metabolism and hypertension and blocks various molecular pathways such as AGE (Advanced Glycation End Product), RAAS (Renin Angiotensin Aldosterone System), PKC (Protein Kinase C), Hexosomamine, and polyol. Individuals are temporarily relieved by available combined treatments like ACE inhibitors and calcium channel blockers for blood pressure control as well as for severe albuminuria conditions, but these therapies have significant adverse health consequences. Herbal preparations play a potential role in the cure of various ailments that come first in the mind for humans which have least or without side effects and are economically stable for consumption. Since these constituents are cost-effective and have minimal side effects, scientifically validated phytochemicals or combined formulations are significant against diabetic nephropathy. This review focuses on the mechanism of receptors and the genes involved in the disease and the potential phytochemicals effectiveness against it.