Serum lipid profile paraoxonase and arylesterase activities in psoriasis

Abstract

Psoriasis is a common chronic and recurrent inflammatory skin diseasewith unknown etiology that has been associatedwith abnormal plasma lipid metabolism and oxidative stress. There are controversial results in the previous studies investigating oxidant/antioxidant systems in psoriasis. The aim of this work was to evaluate dyslipidemia, oxidative stress, total antioxidant capacity and serum paraoxonase (PON1) and arylesterase (ARE) activities in psoriasis, and to look for a correlation between these parameters and lesion percentage in psoriasis. Thirty psoriatic patients and twenty three sex- and agematched healthy volunteers were included in the study. From blood samples, lipid profile, malondialdehyde (MDA) levels, total antioxidant capacity (TAO), serum PON1 and ARE activities were determined. No significant differences between the patients and controls were found in terms of total cholesterol, triacylglycerol (TAG), HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, MDA and TAO levels. Serum PON1 and sodium-stimulated PON1 activities (p<0.05) and ARE activity (p<0.01) were found significantly higher in the patients than in the controls. There was not any significant correlation between lesion percentage and the parameters studied. Copyright © 2009 John Wiley & Sons, Ltd.