Synthesis and in vitro biodegradation of poly(ethylene adipate-co-D,L-lactic acid) copolymers (PLEA)

Abstract

The present research mainly focused on the synthesis and study of biodegradation of poly (ethylene adipate-co-D,L-lactic acid). PLEA were prepared via ring opening polymerization from D,L-lactide and poly(ethylene adipate). PLEA was characterized by 1 H NMR spectra and DSC; results showed that those properties showed high dependence on its composition.In vitro degradation behaviors of PLEA have been systematically investigated up to 12 weeks in phosphate buffer saline solution at 37 °C. The weight and polymer molecular weight were measured as a function of degradation time. Bacterial degradation was completed by investigating the physico-chemical properties using spectroscopy FTIR and DSC.