Development and In-Vitro Evaluation of Cefpodoxime Proxetil Gastro-Retentive Floating Tablets

Abstract

The present study was undertaken with the aim to develop and evaluate Gastro retentive floating tablets of Cefpodoxime proxetil to get drug release up to 12hrs. These tablets were prepared by direct compression method using various bioadhesive polymers like HPMC K4M, HPMC K100M.The formulated gastro retentive floating tablets were evaluated for different parameters such as drug excipient compatability studies, weight variation, thickness, hardness, content uniformity, Invitro Buoyancy studies, In vitro drug release studies performed in 0.1N HCl for 12hrs and the data was subjected to zero order, first order, Higuchi release kinetics and kars mayer peppas graph. All pre and post compression parameters were found to be within limits. From the drug release data among formulations, F8 formulation was found to be optimized when compared with standard/marketed.