Assessment of correlation between HIV infection and tuberculosis with multiple drug resistance

Abstract

Human immunodeficiency virus (HIV) and tuberculosis with multiple drug resistance (MDR TB) are becoming the major problem for national tuberculosis control programs. Conclusions made by various studies investigating the association of HIV infection and multiple drug resistance of tuberculous mycobacteria in tuberculosis patients are not always unambiguous and evident. The objective: to summarize data on the correlation between HIV infection and MDR TB among new cases through the systematic review of published results of studies. Research methods. The quality, accuracy and authenticity of the initial data were assessed. Approximating functions of changes in HIV-TB-MDR and TB-MDR were built for new cases basing on the data of 11 selected studies. The general effect of HIV infection impact factor on TB-MDR was assessed for the studies included into the analysis. Results. Data analysis for the consolidated group of new cases showed that the assessment of the risk of MDR detection was higher in those with TB/HIV co-infection (OR 2.76; 95% CI 2.35-3.24) versus HIV negative tuberculosis patients, which provided the evidence of the existing positive epidemiological correlation between the positive HIV status and MDR TB.