Six new constituents from an Ascomycete, Chaetomium quadrangulatum, found in a screening study focused on monoamine oxidase inhibitory activity

Abstract

A screening study focusing on monoamine oxidase inhibitory activity on the EtOAc extract of an Ascomycete Chaetomium quadrangulatum, which previously gave five unique chromones possessing this activity (chaetoquadrins A - E (1 - 5)), this time afforded six new constituents termed chaetoquadrins F - K (6 - 11) in addition to 1 - 5. The structures of 6 - 11 have been deduced on the basis of spectral and chemical data, and 7 and 8 have shown appreciable monoamine oxidase inhibitory activity. © 2003 Pharmaceutical Society of Japan.