Effect of ethanolic seed extract of Caesalpinia bonducella on mifepristone induced PCOS rats

Abstract

Introduction and Aim: PCOS is a complicated endocrinopathy of women in reproductive age with unknown etiology causing ovulatory dysfunction and metabolic disturbances. The present study investigated the effects of ethanolic seed extract of Caesalpinia bonducella (ESECB) in a mifepristone model of polycystic ovarian syndrome, which has the same clinical and metabolic features as in PCOS women. Materials and Methods: A daily administration of mifepristone (4mg/kg b.w.) to female rats for 8 days induces PCOS by indicating persistent estrous cycle. PCOS induced rats were treated with ESECB 200mg and 400mg/kg b. w. per oral for 28 days and at the end, the weight of the body and reproductive organs were determined. Biochemical parameters were also estimated. Metformin was used as a standard drug. Results: A significant increase (p<0.01)in the weight of the body and reproductive organs as well as hyperglycemia and dyslipidemia were observed in the PCOS induced animals, which were reduced considerably in the ESECB drug treated animals. Among two concentrations the animals which received 400mg/kg b. w. of ESECB drug showed significant effect when comparable to the animals which received 200mg/kg b. w. of ESECB. Conclusion: Based on these observations the ethanolic seed extract of Caesalpinia bonducella (ESECB) can be used as a potential drug in the management of PCOS.