Hydrogel micropillars with integrin selective peptidomimetic functionalized nanopatterned tops: A new tool for the measurement of cell traction forces transmitted through αvβ3- or α5β1-integrins

Abstract

Poly(ethylene glycol) micropillars with gold nanopatterns on top are functionalized with two integrin selective ligands. This platform is a powerful new tool to determine the specific contribution of traction forces involved in cell adhesion mediated by α5 β1- and αvβ3- integrins. Cells adherent via α5 β1-integrins have a tendency to exert higher maximum forces than cells adhering via αvβ3- integrins. © 2013 WILEY-VCH Verlag GmbH 8 Co. KGaA, Weinheim.