Genomic characterization of antimicrobial resistance in food chain and livestock‐associated salmonella species

Abstract

The rising trend of antimicrobial resistance (AMR) by foodborne bacteria is a public health concern as these pathogens are easily transmitted to humans through the food chain. Non‐typhoid Salmonella spp. is one of the leading foodborne pathogens which infect humans worldwide and is associated with food and livestock. Due to the lack of discovery of new antibiotics and the pressure exerted by antimicrobial resistance in the pharmaceutical industry, this review aimed to address the issue of antibiotic use in livestock which leads to AMR of Salmonella. Much attention was given to resistance to carbapenems and colistin which are the last‐line antibiotics used in cases of multi drug resistant bacterial infections. In the present review, we highlighted data published on antimicrobial resistant Salmonella species and serovars associated with livestock and food chain animals. The importance of genomic characterization of carbapenem and colistin resistant Salmonella in determining the relationship between human clinical isolates and food animal isolates was also discussed in this review. Plasmids, transposons, and insertion sequence elements mediate dissemination of not only AMR genes but also genes for resistance to heavy metals and disinfectants, thus limiting the thera-peutic options for treatment and control of Salmonella. Genes for resistance to colistin (mcr‐1 to mcr‐ 9) and carbapenem (blaVIM‐1, blaDNM‐1, and blaNDM‐5) have been detected from poultry, pig, and human Salmonella isolates, indicating food animal‐associated AMR which is a threat to human public health. Genotyping, plasmid characterization, and phylogenetic analysis is important in understanding the epidemiology of livestock‐related Salmonella so that measures of preventing foodborne threats to humans can be improved.