Impact of obstructive sleep apnea on left ventricular mass index in men with coronary artery disease

Abstract

Study Objectives: Left ventricular hypertrophy (LVH) is associated with augmented risk for mortality in patients with coronary artery disease (CAD). These patients often have obstructive sleep apnea (OSA).We aimed to evaluate the relationship betweenOSA and the left ventricularmass index (LVMI) in men with CAD. Methods: Consecutive patients withCADwere recruited and underwent overnight portable monitoring for the assessment of OSA. LVMI was ascertained using highresolutionechocardiography. Univariate andmultivariate regression analyseswere conducted to explore the associations between theOSAparametersand the LVMI levels. Results: Of the 1,053 examined male patients with CAD, 425 (40.4%) had moderate-to-severe OSA (respiratory event index ≥ 15 events/h). The prevalence of LVH (LVMI > 125 g/m2) was 36.0% (n = 379). The mean LVMI values increased with increasing OSA severity (P < .001) times increased risk of LVH than those without OSA (respiratory event index < 5 events/h) independent of confounders. The minimumoxygen saturation levels were the strongest factor correlated with LVMI (β = -0.299, P =.004) of several OSA indices. Patients with minimum oxygen saturation < 70% had an adjusted odds ratio of 3.62 (95% confidence interval 1.81-7.25, P