A FATal combination: Fibroblast-derived lipids and cancer-derived autotaxin promote pancreatic cancer growth

Abstract

In this issue of Cancer Discovery, Auciello and colleagues find that in the pancreatic cancer microenvironment activated fibroblasts secrete specific lipids that provide a source of biomass production and signaling molecules for cancer cells, fueling their proliferation and migration. Targeting of this stromal–tumor metabolic cross-talk impairs pancreatic cancer progression and represents a new potential therapeutic opportunity.