Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2

Abstract

The matrix metalloproteinase-2 (MMP-2), over-expressed in most cancers, induces TH2 polarization by conditioning dendritic cells to over-express OX40L and down-regulate IL-12p70 through the degradation of the type-I IFN receptor IFNAR1. Elucidating mechanisms underlying detrimental tumor-associated type-2 responses represent a crucial step in designing effective immune therapies to treat cancer patients. © 2012 Landes Bioscience.