Promoter polymorphism (T-1486C) of TLR-9 gene is associated with knee osteoarthritis in a Turkish population

Abstract

In this study, we aimed to determine whether TLR-9 T-1486C SNP was associated with susceptibility to OA in the Turkish population. The study group comprised 272 patients with Grade 2-3-4 knee OA according to the Kellgren-Lawrence scoring system and the control group was formed of 296 individuals with Grade 0–1. The TLR-9 genotype were assessed by real-time polymerase chain reaction. An analysis of TLR-9 promoter −1486T/C polymorphism revealed that the −1486CC genotype appeared to have a higher risk for OA and −1486TT and −1486CT genotypes have a protective effect against the development of OA (crude OR = 0.473, 95% CI = 0.297–0.754, p = 0.002, adjusted OR = 0.531, 95% CI = 0.326–0.864, p = 0.011). This study indicate that there is a correlation of TLR-9 T-1486C gene polymorphism with advanced knee OA in a Turkish population. Changed in TLR expression due to different allelles may cause osteoarthrith development outcome cartilage degeneration. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2484–2489, 2017.