Phosphatase and tensin homolog deleted on chromosome10 (pten) and ph domain and leucine-rich repeat phosphatase cross-talk (phlpp) in cancer cells and in transforming growth factor β-activated stem cells

Abstract

Background: The oncogene Akt is regulated by phosphatases.Results: Akt phosphatases cross-talk in prostate cancer cells and intransforming growth factor β1-activated stem cells but notin non-transformed cells.Conclusion: This back-up mechanism facilitates invasive migration of prostate stem and cancer cells.Significance: Characterization of Akt regulation may lead to a better understanding of tumor development and to novelstrategies for treatment. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.