An efficient one-pot three-component synthesis of tetrakis(uracil) and their corresponding bis-fused derivatives

Abstract

A concise and efficient approach to tetrakis(uracil) derivatives by the reaction of bis(aldehydes) with four equivalents of 6-aminouracil is reported. Also, the synthesis of bis(pyrimido[4,5-b]quinolones) and bis(indeno-[2',1':5,6]pyrido[2,3-d]pyrimidine) derivatives has been accomplished by a three-component reaction involving bis(aldehydes), 6-aminouracil and the appropriate cyclic 1,3-diketone. The method involves domino Knoevenagel condensation / Michael addition reaction sequences.