Abstract
A polymeric nanocarrier: Polymersomes tagged with a dodecamer peptide that recognizes gangliosides GM1 and GT1b are shown to cross the blood-brain barrier, both in an in vitro model and in vivo (see picture). The combination of polymeric vesicles with a small GM1-binding peptide and GM1/GT1b gangliosides as targeting sites for blood-brain barrier transport is unprecedented. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Georgieva, J. V., Brinkhuis, R. P., Stojanov, K., Weijers, C. A. G. M., Zuilhof, H., Rutjes, F. P. J. T., … Zuhorn, I. S. (2012). Peptide-mediated blood-brain barrier transport of polymersomes. Angewandte Chemie - International Edition, 51(33), 8339–8342. https://doi.org/10.1002/anie.201202001
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