Veno-occlusive disease of the liver in renal transplant patients

Abstract

In summary, tacrolimus (especially in the event of an overdose), alone or in combination with valaciclovir, azathioprine or viral hepatitis, may give rise to VOD. It is therefore necessary to monitor tacrolimus levels and liver parameters throughout treatment. In the event of clinical or biochemical abnormalities, a liver biopsy should be performed for the diagnosis of VOD, and tacrolimus should be withdrawn.