Physiological and Clinical Assessment of the Effect of the Musculotropic Agent Mebeverine on the Human Colon

Abstract

A new anti-spasmodic preparation which has a direct musculotropic effect has been studied. Mebeverine results in a diminution of exaggerated colonic motility as tested, by the measurement of intraluminal pressures in the sigmoid colon in man. In a double-blind controlled trial assessed by sequential analysis Mebeverine was shown to be superior t6 a placebo preparation in relief of symptoms assumed to be arising from the irregular activity of the lower alimentary tract. © 1965, British Medical Journal Publishing Group. All rights reserved.