Antibacterial activity of TE-031 (A-56268), a new macrolide antibiotic

Abstract

The in vitro and in vivo antibacterial activity of TE- 031 (A-56268) was comparedwith those of erythromycin (EM), josamycin (JM) and other antibiotics. The following results were obtained. 1. TE-031 had the same antibacterial spectrum as EM, being active against aerobicGram-positive and -negative bacteria (B. catarrhalis, N. gonorrhoeae, H. influenzae), anaerobic bacteria, L-form bacteria and M. pneumoniae. 2. TE-031 was equally or slightly more active than EM and more active than JM against 388 strains of clinical isolates. 3. TE-031 showed bactericidal activity against H. influenzae, as did EM. 4. TE- 031 was more effective than EM and JM against systemic, subcutaneous and respiratory tract infections in mice. © 1988, Japanese Society of Chemotherapy. All rights reserved.