Synthesis, single crystal x-ray structure, and antimicrobial activity of 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-[2-(morpholin-4-yl)ethyl] sulfanylpyrimidin-4(3 h)-one

Abstract

Synthesis, X-ray structure and antimicrobial activity of 6-(1,3-benzodioxol-5-ylmethyl)-5-ethyl-2-[2-(morpholin-4-yl)ethyl] sulfanylpyrimidin-4(3H)-one (8) are reported. Compound 8 exhibited activity towards S. aureus with MIC value of 0.0619 mol/mL while it showed activity towards B. subtilis, B. cereus, C. albicans, and A. niger with MIC = 0.1859 mol/mL. Single crystal X-ray structure of the title compound 8 confirmed its S-alkylation. The title compound crystallizes in the triclinic, P -1, a = 11.1220 (5) Å, b = 12.2241 (5) Å, c = 21.5246 (9) Å, = 88.958 (2)°, β = 79.836 (2)°, γ = 79.384 (2)°, V = 2830.9 (2) Å3, Z = 6, R (F) = 0.046, w R (F 2) = 0.110, T = 100 K. The crystal structure is stabilized by weak intermolecular C-H O and N-H O hydrogen interactions. © 2014 Mohamed I. Attia et al.