Abstract
From γ-irradiated oxygenated aqueous solutions of DNA, 2-deoxy-tetrodialdose (1) and 2-deoxy-pentos-4-ulose (2) have been isolated as free sugars. The formation of 1 indicates that in the presence of oxygen the DNA strand is not only broken by mere phosphate ester cleavage but also by C —C-bond rupture in the sugar moiety. Such a process has not been encountered in deoxygenated solutions so far. The mechanism for the formation of 1 is discussed. © 1975, Verlag der Zeitschrift. All rights reserved.
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Dizdaroglu, M., Schulte-Frohlinde, D., & von Sonntag, C. (1975). Radiation Chemistry of DNA, II: Strand Breaks and Sugar Release by γ-Irradiation of DNA in Aqueous Solution. The Effect of Oxygen. Zeitschrift Fur Naturforschung - Section C Journal of Biosciences, 30(11–12), 826–828. https://doi.org/10.1515/znc-1975-11-1225
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