Mitochondrial permeability transition, F1FO‐ATPase and calcium: an enigmatic triangle

Abstract

In response to calcium mitochondria can undergo a permeability transition—a sudden increase of the permeability of the inner mitochondrial membrane to ions and solutes resulting in cell death. Salvatore Nesci discusses recent advances in the identification of the structure that forms the mitochondria permeability transition pore. [Image: see text]