Effects of chronic high-level manganese exposure on male behavior in the Japanese quail (Coturnix coturnix japonica).

Abstract

Male Japanese quail were chronically exposed to 5000 ppm manganese (Mn) as particulate manganese oxide (Mn3O4) in their diet from hatching to 75 days of age. No decrements in growth or in other indices of general toxicity were noted. There were significant (P less than .05) age-related increases in general locomotor activity in the control group, although no significant (.05 less than P less than .10) increases were seen in the Mn-treated group. Both control and Mn-treated groups had significant (P less than .05) age-related increases in aggressive behavior with an overall significant (P less than .05) treatment-related depression. Serum testosterone concentration was only slightly depressed (.05 less than P less than .01) in the 75 day-old, Mn-treated quail. Both the control and Mn-treated quail had higher liver Mn concentrations than previously reported in rodents. Both control and Mn-exposed quail accumulated 5 to 10 times more Mn in their livers than similarly treated rodents. This study indicated that the Japanese quail was less sensitive to particulate Mn3O4 exposure than rodents treated comparably.