Improved conversion of dihydrooroidin to oroidin and ugibohlin

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Abstract

Dihydrooroidin was converted to the marine natural product oroidin in 75 % overall yield by chlorination of the 2-aminoimidazole unit in DMF, followed by dehydrochlorination. The natural product ugibohlin was synthesized for the first time by ring opening of dibromoisophakellin, which was obtained in a quantitative manner by heating the free base of dibromophakellin in neutral aqueous solution. © 2009 Verlag der Zeitschrift für Naturforschung, Tübingen.

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Moldovan, R. P., & Lindel, T. (2009). Improved conversion of dihydrooroidin to oroidin and ugibohlin. Zeitschrift Fur Naturforschung - Section B Journal of Chemical Sciences, 64(11–12), 1612–1617. https://doi.org/10.1515/znb-2009-11-1247

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