Influence of silver nanoparticles on the tissue reaction of polyacrylic acid-based gel

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Abstract

Purpose: To study the influence of silver nanoparticles (AgNP) on tissue reaction when incorporated into a polymeric matrix of polyacrylic acid-based (Carbopol®) gel as a proposal for a new low-cost type of biomaterial that is simple to manufacture for use as an antimicrobial and antioxidative dressing. Methods: In-vivo tests of implantation in the subcutaneous tissue of the back of rats were performed using polyethylene tubes in three situations: empty, only the gel, and gel incorporated with AgNP. Then, the tissue reaction was studied by counting inflammatory cells. Additionally, in-vitro tests of the antioxidative and antimicrobial activity of AgNP were performed. The radical 2,2 diphenyl-1 picrylhydrazyl (DPPH) was used to test the antioxidative activity of AgNP using electron spin resonance. The antimicrobial activity of AgNP was determined by minimum inhibitory concentration against the microorganisms: Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Results: The results indicated that AgNP presents antioxidative activity and was able to inhibit the growth of the microorganisms tested. The addition of AgNP in Carbopol® did not alter the tissue inflammatory response (p>0.05, Kruskal-Wallis’s test). Conclusion: The new biomaterial is promising for future use as a dressing for its beneficial properties for regenerative processes.

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Bonete, J. M., Tamashiro, J. R., de Paiva, F. F. G., de Queiroz-Fernandes, G. M., Guidelli, É., Baffa, O., & Kinoshita, A. (2022). Influence of silver nanoparticles on the tissue reaction of polyacrylic acid-based gel. Acta Cirurgica Brasileira, 37(5). https://doi.org/10.1590/acb370504

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